Compound salvia pellet protects cardiomyocytes against myocardial ischemia and inhibits apoptosis via the Akt-eNOS signaling pathway.[68] Moreover, it may have extensive effects on four metabolites (hypoxanthine, xanthine, inosine, and allantoin) in the pathway of purine metabolism which contribute to a decrease of oxygen-free radical.[69] While nitrates dilate veins, arteries, and coronary arteries by relaxing vascular smooth muscle. This evidence concerns the gene AKT1 and myocardial ischemia.