Among IBD patients, 30% to 50% occurred platelet aggregation spontaneously or hypersensitivity to low concentration of stimulus.[12] Investigators depicted that the levels of some coagulation enzymes like fibrinogen, factors V, VII, VIII, X, XI, and XII, prothrombin fragment 1 + 2, and the thrombin-antithrombin complex (TAT) were changed in IBD patients.[13] Normally, endothelial cells provide an antiadhesive and selectively permeable exchange barrier. This evidence concerns the gene F2 and inflammatory bowel disease.