THBD and inflammatory bowel disease: It was demonstrated that the impaired endothelial cell in IBD patients was associated with increased expression of endothelial protein C receptor, thrombomodulin and disease activity, and inflammatory markers.[2,14] Inflammation and the coagulation system interacted with each other, and an in vitro study had confirmed that inflammation could disturb the balance of coagulation, activate the system of coagulation, then promote thrombosis.