Similar to the results seen using high doses, IFN-γ responses in mice vaccinated with S10010–18 and S10020–28 [6/13 (46.1%) and 7/13 (53.8%), respectively] are not significantly higher compared with those seen in animals inoculated with saline [S10010–18: 66.7% (8/12); S10020–28: 66.7% (8/12)] or those developing T1D spontaneously [S10010–18: 61.3% (19/31); S10020–28: 48.4% (15/31)] (Fig. 5C, D) (P > 0.05; Fisher’s exact test). Here, IFNG is linked to type 1 diabetes mellitus.