To investigate a larger cohort with less bias towards chromosome 21 abnormalities, we screened publicly available SNP array data from 648 presentation B-ALL [28], identifying just two with SH2B3 deletions, one with tetrasomy 21 and the other with no recorded evidence of a chromosome 21 CN abnormality (Supplementary Figure 2 and Supplementary table 4). The gene discussed is SH2B3; the disease is acute lymphoblastic leukemia.