SHON nuclear expression was associated with favourable clinicopathological features including hormone receptor (ERα+, PR+ and AR+) positivity, 4-IHC luminal A (ERα+/HER2−/low proliferation phenotype), tubular BC, low histological grade, low mitotic index, low proliferation index (Ki67), low pleomorphism, and MDM4 overexpression (Table 1). This evidence concerns the gene AR and breast cancer.