Therefore, it was not surprising that SHON cytoplasmic expression was associated with a better survival outcome in our adjuvant ERα− BC cohort whereas it was associated with poor survival in the neoadjuvant cohort (which was predominantly ERα+ BC) who received pre-operative chemotherapy followed by 5-year adjuvant tamoxifen although SHON cytoplasmic expression was associated with a higher pCR. Here, HIP1 is linked to breast cancer.