High chromosomal instability and aneuploidy are hallmarks of malignant cells and confer vulnerability to chemotherapy.42 We demonstrated that SHON nuclear expression was highly associated with the expression of DNA repair proteins and a low proliferation index (Ki67), suggesting that SHON may be an important driver for genetic stability in BC, and SHON dysregulation could contribute to chromosomal instability. This evidence concerns the gene HIP1 and breast cancer.