SHON cytoplasmic expression was associated with aggressive clinicopathological features including absence of hormone receptor (ERα− and PR−) positivity, basal-like phenotype, ERα−/HER2−, triple negative, invasive ductal carcinoma of no specific type (IDC-NST), higher histological grade, tubular dedifferentiation, pleomorphism, high mitotic index, and higher levels of proliferation markers (all p < 0.01) (Table 2). The gene discussed is NR4A1; the disease is invasive ductal breast carcinoma.