NLRP3 and Crohn disease: Gain-of-function polymorphisms in the NLRP3 inflammasome resulting from gene polymorphisms such as NLRP3 (Q705K) and loss-of-function in relation to CARD8 (C10X) are associated to RA and Crohn’s disease, and some evidence for a combined effect of these polymorphisms have been described6,7.