BCAR1 and central nervous system cancer: p130Cas overexpression has been detected in human breast, prostate, ovarian, lung, colorectal, pancreatic and hepatocellular carcinoma, as well as in glioma, melanoma, anaplastic large cell lymphoma and chronic myelogenous leukemia, although the exact mechanisms that drive p130Cas overexpression in cancer have not yet been identified6–8.