We also performed global miRNA and mRNA profiling in CD4+ T cells purified from spleen of MRL/lpr lupus-prone mice (MRL) and compared with the C57BL/6 (B6) and isolated miR-200a-3p, which is involved in the hypoproduction of IL-2 in T cells by targeting CtBP2 complex10. The gene discussed is CD4; the disease is systemic lupus erythematosus.