Interestingly, the treatment with PEDF reduced the baseline levels of DGAT1 protein (PC-3 PEDF vs PC-3 CTR: 69.5 ± 0.7 vs 123.5 ± 1.5; P < 0.001), thus, allowing a negative feedback loop to suppress endogenous DGAT1 protein in cancer cells. Here, DGAT1 is linked to cancer.