The majority (70.5%) of non-coding variants were located in the largest intron, intron 1, which spans 13,285 bp (76.7%) of the 17,321 bp length of MYOC. For comparison, there were 574 total SNPs in the 1000 Genomes Project European population (1000gEUR) in MYOC. There were 105 rare (AF < 5%) variants in POAG and 134 rare (AF < 5%) variants in 1000gEUR, and these had a similar distribution across the MYOC gene (Fig. 1F and G). Here, MYOC is linked to open-angle glaucoma.