ACHE and chronic kidney disease: The results indicate that the activity of the enzyme did not ameliorate, and the diminished AChE activity persisted significantly in the cortex, striatum, hippocampus, and substantia nigra of CKD mice by 46.74%, 24.43%, 43.87% and 25.58% respectively, compared to the control (Supplementary Figs S1 & S2).