ACHE and chronic kidney disease: Analysis from the brain tissue homogenates of these respective regions, following Ellman’s method, the activity of AChE (in mu/mg protein) was found to be 28.23 ± 2.41, 13.01 ± 1.99, 39.34 ± 4.42, 35.67 ± 5.55, 25.17 ± 2.42, 33.61 ± 3.69 in prefrontal cortex, cerebral cortex, striatum, amygdala, hippocampus and substantia nigra respectively in control mice, while in CKD mice the same was 17.57 ± 3.76, 7.29 ± 1.27, 28.69 ± 3.10, 21.01 ± 3.28, 14.37 ± 2.35 and 24.01 ± 2.45 respectively (Fig. 6M; Supplementary Table 2).