SOD1 and chronic kidney disease: However, in the striatum of the CKD mice, alterations in the activities of SOD (Fig. 12A) and Catalase (Fig. 12B), elevated lipid peroxidation (Fig. 12C), astrocytosis (Fig. 13), increase in NOS-active neurons (Fig. 14) and dysfunction of mitochondrial complexes (Figs 9, 10 and 11) were prevalent; while alterations in SOD (Fig. 12A) and Catalase (Fig. 12B) activities, and astrocytosis (Fig. 13) have been observed in the substantia nigra of the mice.