Due to different study settings, the prevalence of anaemia in the HIV patients ranges from 20% to 84% [5–7] in the world and the risk factors are also different including sex, age, educational status, antiretroviral therapy (ART) status, stage of HIV disease, CD4+ T lymphocyte count, HIV RNA loads and presence of opportunistic infection (OI) [7–10]. This evidence concerns the gene CD4 and anemia (phenotype).