In addition,acetylated chromatin ChIP-Seq analysis of pancreatic juice found a Chromosome 10(41876818...41877334) genetic locus containing RET, a proto-oncogeneencoding a tyrosine kinase implicated in medullary thyroid cancer and multipleendocrine neoplasia.17 Quantitative PCR analysis of ChIP-isolated chromatin from juice of 17patients detected RET gene loci in 3 of 4 ampullary adenocarcinomaand 1 of 3 neuroendocrine tumors in samples collected at day 3 or later in thepostoperative period (Table3). The gene discussed is RET; the disease is medullary thyroid gland carcinoma.