The cluster coefficient analyses revealed a distinct profile for HBV monoinfection with GM-CSF-IL4-IL2-IFNγ-IL12p70; IL-10- IL-6-TNF-α) grouping together and a different, unique profile for HBV/HIV infection with (GM-CSF- IL-4- IL-2- IFN-γ- IL12p70; IL-7- IL-10 -IL1-β grouping together. Here, IL2 is linked to HIV infectious disease.