The present study aimed to investigate the prevalence of specific immunoglobulin E and G <b>(</b>IgE and IgG) against <i>A.fumigatus</i> in asthmatic patients.<h4>Materials and methods</h4>This study was conducted on 200 consecutive patients with moderate to severe asthma referring to Masih Daneshvari hospital Tehran, Iran, from January 2016 to February 2018. Here, IGHE is linked to asthma.