RIPK1 and amyotrophic lateral sclerosis: This is what Ito et al. (2016) have done with the kinase inhibitor of RIPK1, Nec1s, but since that study only reports on onset of motor dysfunction and on myelin decompaction, we believe that the potential therapeutic role of targetting key determinants of necroptosis in ALS and related neurodegenerative disorders remains to be established.