The small molecule S63845 (Servier Laboratories, Suresnes, France and Novartis, Basel, Switzerland) [174] has been shown to bind with high affinity to the BH3-binding groove of MCL-1, resulting in apoptosis of MCL-1–dependent multiple myeloma, leukemia, and lymphoma cells [174]. The gene discussed is MCL1; the disease is AL amyloidosis.