CARD10 and viral infectious disease: Considering the ubiquitination and degradation of CARMA3 upon VSV infection, it will be interesting to determine whether some virus, such as influenza virus, Ebola, SARS, and MERS, may modulate the mechanism of proteasomal degradation of CARMA3, which may regulate the expression of pro-inflammatory cytokines and type I IFN expression, and result in virus infection-associated cytokine storm, thereby contributing to the pathogenesis of virus infection.