To determine the functional role of CARMA3 in antiviral innate immune response, Jiang et al. challenged CARMA3-deficient mice with influenza virus or vesicular stomatitis virus and found that CARMA3-deficient mice showed more resistance to virus infection, which was characterized by less weight loss, lower viral yield, and greatly attenuated lung injury, suggesting that CARMA3 plays a negative role in antiviral response against virus infection (15). The gene discussed is CARD10; the disease is viral infectious disease.