In another study, migration was enhanced and detachment-induced apoptosis was inhibited by T4 in prostate cancer cells, while tetrac, the αvβ3 inhibitor, reversed these effects through diminished activity of the MAPK pathway and inhibited expressions of XIAP, MMP2 and VEGF, suggesting involvement of the integrin in these effects (36). Here, VEGFA is linked to Familial prostate cancer.