In particular, a recent study demonstrated that the expression of the GR gene (Nr3c1) in various nuclei of the hypothalamus (in particular, in PVN) and the GR regulator (FKBP51) in old mice representing the progeny of females with diet -induced obesity, increased in basal conditions, and in response to stress exposure (79). This evidence concerns the gene NR3C1 and obesity due to melanocortin 4 receptor deficiency.