In particular, a recent study demonstrated that the expression of the GR gene (Nr3c1) in various nuclei of the hypothalamus (in particular, in PVN) and the GR regulator (FKBP51) in old mice representing the progeny of females with diet -induced obesity, increased in basal conditions, and in response to stress exposure (79). Here, FKBP5 is linked to obesity due to melanocortin 4 receptor deficiency.