The purpose of the present study was to investigate the individual and age-related features of the glucocorticoid negative feedback in regulation of HPA axis on the model of rhesus monkey females with control standard behavior and with depression-like and anxiety-like behavior using functional tests with agonists of MR (fludrocortisone) and GR (dexamethasone). Here, NR3C2 is linked to depressive symptom measurement.