Recent work from our laboratory showed that blood MCP-1/CCL2 levels have selective cognitive and neuroanatomical relevance in both typical aging as well as early stages of Alzheimer’s disease (AD), such that higher MCP-1/CCL2 levels are related to worse episodic memory function and smaller left medial temporal lobes. This evidence concerns the gene CCL2 and early-onset autosomal dominant Alzheimer disease.