ADCY3 and autism: In summary, this comparative phosphoproteomic profiling has generated several interesting findings: (1) AC3 ablation leads to decreased activity of proline-directed kinases in the frontal cortex; (2) There is a gender-biased phosphorylation in 204 proteins, 31% of which are associated with ASD; (3) Four delta catenin family members, all associated with autism, contain gender-biased phosphorylation sites.