Consistent with multivariate analysis, Kaplan–Meier survival analysis showed that HCC patients with advanced TNM stage, decreased Wnt1 expression, decreased Wnt3 expression, decreased Wnt5B expression, increased Wnt6 expression and increased Wnt8A expression had a worse OS than the counterpart (all P < 0.05) (Fig. 1). The gene discussed is WNT8A; the disease is hepatocellular carcinoma.