For instance, Cx43 overexpression can enhance the sensitivity to common chemotherapeutic drugs such as doxorubicin, fluorouracil and oxaliplatin in human gastric cancer cells [128], etoposide, paclitaxel and doxorubicin in glioma cells [129], and artesunate in MCF-7 breast cancer cells [130]. Here, GJA1 is linked to central nervous system cancer.