NPC1 and cancer: Based on the facts that the dysregulation of many NPC components is found in the different types of cancer and that various nuclear factors interacting with them, such as chromosomal maintenance 1 (CRM1, also known as exportin1), karyopherin family (KPNA2 and KPNB1), and chromosome segregation gene, contribute to the progression of cancer29,35–37, more attention is being focused on developing therapeutic drugs using transport factors35,38.