Using CD11b-diphtheria toxin receptor (DTR) transgenic mice to selectively deplete macrophages at different stages in carbon tetrachloride-induced liver injury, Duffield et al. showed that macrophage depletion when liver fibrosis was advanced resulted in amelioration of fibrosis, whereas macrophage depletion during recovery phase, led to a failure of resolution with impaired matrix degradation10. Here, HBEGF is linked to Hepatic fibrosis.