NRF1 and hyperinsulinism: Importantly, several significant pathological phenotypes were developed in different transgenic mice (expressing distinct mutants of loss-of-function of Nrf1), including embryonic lethality, fetal anemia, lipid metabolic disorder, obesity, fatty liver, NASH, liver cancer, neurodegenerative diseases, hyperinsulinemia, diabetes, Warbug effect with high glycolysis.