In this study, we found that AF38469 or Si-Sor suppressed the levels of p-GSK-3β and β-catenin, whereas the inhibitory effect of AF38469 or Si-Sor on β-catenin expression were reversed by a GSK-3β inhibitor (SB216763) or Si-GSK, suggesting that GSK-3β/β-catenin is positively regulated by sortilin in GBM. The gene discussed is SORT1; the disease is glioblastoma.