In addition, we observed that both AF38469 and Si-Sor could decrease the levels of mesenchymal-related markers, such as N-cadherin, vimentin, MMP-2, and MMP-9, and increase the level of T-cadherin, suggesting that sortilin could enhance or at least maintain the mesenchymal transition of GBM. This evidence concerns the gene SORT1 and glioblastoma.