CDH1 and nonpapillary renal cell carcinoma: Intriguingly, E-cadherin was strongly polarized in cancer organoids, suggestive of epithelial-mesenchymal transition state and aggressiveness (Fig. 5a), in line with reverse phase protein array (RPPA) (Supplementary Fig. 13B) and FACS analysis in normal (Supplementary Fig. 1) and ccRCC cultures previously published46.