PPARD and obesity due to melanocortin 4 receptor deficiency: Chloroquine (CQ) is a well-known pharmacological inhibitor of autophagic and lysosomal function used in vivo22 To understand the role of autophagy in PPARδ activation-induced lipid turnover in vivo, we co-administered an autophagy inhibitor to PPARδ agonist-treated genetic obesity models.