DDIT3 and ovarian cancer: Lei et al. demonstrated that downregulation of ANKRD1 made ovarian cancer cells sensitive to apoptosis induced by cisplatin and ER stress, which is related to the guidance of GADD153. ANKRD1 has an important role in regulating the apoptosis of ovarian cancer cell lines, and it could represent a new molecular target to increase the sensitivity of ovarian cancer to chemotherapy40.