IL6 and neoplasm: IL-6 expression, on the other hand, was increased approximately 20-fold in the cortical and trabecular bone of tumor-bearing mice injected with MDA-MB-231GFP/Luc2 cells alone when compared to mice injected with MDA-MB-231GFP/Luc2 cells plus either EO-231 or MC3T3-E1 cells (Fig. 3).