AKT1 and neoplasm: At the same time, NKG2D receptor expression on tumor cells binding to NKG2DL expressed by adjacent tumor cells leads to autostimulation of the PI3K/AKT/mammalian target of rapamycin (mTOR) oncogenic signaling pathway, promotes tumor angiogenesis and metastasis, and enhances tumor proliferation (Fig. 3) [39].