In addition, we describe that radiation induces the functional over-expression of KCa3.1 channels, and that the inhibition of these channels with 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole (TRAM-34) counteracts the expression of the pro-invasive genes induced by radiation in tumor cells. The gene discussed is KCNN4; the disease is neoplasm.