Following mass spectrometry and functional analysis, it was found that mTORC1/2 and Eukaryotic Initiation Factor (EIF) signaling complexes interact with CFTR, mTOR is activated in CF bronchial epithelial cells, and the PI3K/Akt/mTOR pathway is inhibited in CF. The gene discussed is AKT1; the disease is cystic fibrosis.