While further work is required to unravel the mechanisms, based on our observation that cancer patients display a highly patient-specific phenotypic imprint, specific expression patterns of the investigated molecules and particularly RANK/RANKL on lymphocytes and platelets, it is tempting to speculate that this “immunologic phenotype” may influence disease pathophysiology and could serve as further prognostic factor when established and correlated with disease progression upon analysis of a larger patient cohort. The gene discussed is TNFRSF11A; the disease is cancer.