As platelets protect tumor cells from NK cell attack and TNFR family members like the GITR/GITRL molecule system contribute to the same, we next assessed the expression pattern of the immunomodulatory TNF family members CD40L, GITRL, LIGHT, OX40L, and RANKL on platelets from BC and CC patients as well as HD. This evidence concerns the gene TNFRSF1A and breast cancer.