It is well known that LRP6 (low-density lipoprotein-related receptors 6) is a co-receptor of WNT that transmits the canonical Wnt/β-catenin signaling cascade, which has been associated with many diseases including Alzheimer’s disease [26] and coronary artery disease (CAD) [27,28]. This evidence concerns the gene LRP6 and early-onset autosomal dominant Alzheimer disease.