Our main findings were: (1) a possible role of eight SNPs located in TNFAIP3, TNIP1, and MyD88 genes on susceptibility to infection and septic shock, but this association was lost after adjusting for multiple comparisons; (2) 5 of the 33 SNPs analyzed were associated with a higher risk of death in septic shock patients (TNFAIP3 [rs6920220], TNIP1 [rs73272842, rs3792783, rs7708392], and MyD88 [rs7744]). Here, TNFAIP3 is linked to Shock.