These observations, together with the lactate dependence of KIF20A expression as shown in Figure 2, suggest that KIF20A plays an important role in microtubule dynamics and cell motility regulation, especially in the context of lactate-enriched environment of hepatocellular carcinomas, providing a potential therapeutic target for metastatic hepatocellular carcinoma. Here, KIF20A is linked to hepatocellular carcinoma.