NOTCH1 and melanoma: These included NOTCH1, prototype of the NOTCH receptor family, JAG2, a NOTCH ligand linked to vasculogenesis and the EMT, HES5, a NOTCH1-activated transcriptional repressor involved in neural stem cells induction [72,73], DVL1, hub of the interactions between Notch and Wnt signaling [74], and CTBP1, a transcription regulator sensitive to the reduced form of nicotinamide-adenine dinucleotide (NADH), that in melanoma cells links NOTCH signaling to the drop of the intracellular NAD+:NADH ratio caused by aerobic glycolysis [75,76].