This notion highlights that anti-MET and anti-RON therapy can be effective as the first line of intervention in aforementioned addicted cases, whereas it is certainly more relevant to block MET and RON in cases of advanced neoplasms that exploit the activation of the invasive growth program to promote distant dissemination (Figure 2) On this basis, our work hypothesis has been focused on the analysis of the activation status of scatter factor receptors in brain metastases from NSCLC. This evidence concerns the gene MET and non-small cell lung carcinoma.