Likewise, NRAS-Q61K and NRAS-Q61R mutations in skin and blood cancers [8]; PIK3CA-E545K and PIK3CA-H1047R mutations in breast, lung, and colon cancers [9]; and the C-Kit-D816V mutation in blood cancer [10] are reported to commonly and frequently occur. This evidence concerns the gene NRAS and colonic neoplasm.