N-myc downstream regulated genes (NDRGs), a family of proteins consisting of four members (N-myc downstream regulated gene 1 (NDRG1), N-myc downstream regulated gene 2 (NDRG2), N-myc downstream regulated gene 3 (NDRG3), and N-myc downstream regulated gene 4 (NDRG4)), play important functional roles in cancer biology, namely in tumor suppression, metastatic suppression, and oncogenesis [19]. The gene discussed is NDRG1; the disease is cancer.