In the present study, we found that ectopic MT3 overexpression in HT1376 and T24 cells blocked gene expressions of NDRG1, NDRG2, and MASPIN, but not NDRG3. In vitro and in vivo studies have shown that NDRG1-induced expression downregulated the growth of bladder carcinoma cells [39]. The gene discussed is MT3; the disease is urinary bladder carcinoma.