NFKB1 and neoplasm: That the activation of caspase-mediated apoptotic pathways is a strategy to induce the destruction of tumor cells is confirmed by the experiments of Jang and collaborators which demonstrate that transfection of ANT1 triggers apoptosis induction in the MDA-MB-231breast cancer cell line by inactivating NF-κB and increasing the expression of Bax [47].