Overall, a role of TRPV1 was demonstrated in diabetic neuropathy, post-herpetic neuralgia, postsurgical neuropathic pain, complex regional pain syndromes, peripheral neuropathic pain, bone cancer pain, chronic inflammatory pain, irritable bowel syndrome, bladder cystitis, rheumatoid arthritis, and osteoarthritis [4,45,54,55,56]. The gene discussed is TRPV1; the disease is bone cancer.