RELA and ependymoma: In fact, the RelA gene is a proto-oncogene that encodes the RelA subunit (also known as p65) of the NF-kappa-B (NF-κB) transcription factor, which is involved in many cellular processes and in the progression of many diseases, such as Ependymoma and Reticuloendotheliosis, and most importantly PCa [61].