NOTCH3 and Familial prostate cancer: As we mentioned before, losses in 1q21.1-21.2 are found significantly more in EOCRC [13]; losses in 11q14.1-14.3 have been associated with aggressive behaviors and familial linkage, albeit in prostate cancers [18]; gains in 19p13.12 may be related with NOTCH3 expression or function [19].