Importantly, mono-allelic mutations in certain FA genes including FANCD1 (BRCA2), FANCS (BRCA1), FANCN (PALB2), FANCM, FANCJ (BRIP1), and FANCO (RAD51C) that are believed to operate downstream in the pathway and implicated in HR are associated with sporadic breast and ovarian cancer [24,25]. The gene discussed is BRCA1; the disease is ovarian cancer.