Thus, deletion of either pyruvate kinase M1 isoform (PKM1) or lactate dehydrogenase A (LDHA) genes, the most expressed glycolytic genes in murine bone marrow cells, induces HSCs and progenitor cells defects at the level of normal hematopoiesis and impairs leukemia development in mouse leukemia models [147]. This evidence concerns the gene LDHA and leukemia.