One of the few studies addressing the role of mitophagy in leukemia was a recent study by Pei and coworkers showing that primitive AML leukemic stem cells possess a high expression of the mitochondrial dynamic regulator FIS1 and a unique mitochondrial morphology; FIS1 loss attenuates mitophagy and impairs AML LSC potential [178]. The gene discussed is FIS1; the disease is acute myeloid leukemia.