CYBB and acute myeloid leukemia: The increased content of mitochondria in AML leukemic blasts seems to be related to a peculiar mechanism of transfer of mitochondria from bone marrow stromal cells to leukemic blasts through AML-derived tunneling nanotubes; this organelle transfer process requires the NADPH oxidase-2 (NOX2) activity generating superoxide, which stimulates stromal cells to release mitochondria [191].