FLT3 and acute myeloid leukemia: Although targeting FLT3-ITD alone resulted in the elimination of the large majority of AML cells, few kinase-resistant leukemic cells survived to the treatment; Dynamic BH3 profiling showed that kinase-resistant leukemic cells are sensitive to BCL-2 inhibitor: co-treatment with kinase inhibitor and BCL-2 inhibitor resulted in complete eradication of human AML cells resistant to kinase inhibition [272].