MTOR and acute myeloid leukemia: Other observations have shown that the antileukemic drug cytarabine, in spite of its antileukemic effects, promotes also mTOR-dependent cytoprotective effects in primary AML blasts and that blocking autophagy by treatment with bacilomycin A1 or the lysosomotropic agent chloroquine elicited a marked increase of the cytotoxic effects of cytarabine on leukemic blasts [348].