RUNX1 and acute myeloid leukemia: EVI1 proto-oncogene is deregulated by chromosomal translocations in some cases of AML; EVI1 overexpression in hematopoietic cells alters cellular metabolism and promotes overexpression of genes related to purine and pyrimidine metabolism, amino acid metabolism (alanine, aspartate, glutamate, arginine and proline), the pentose phosphate pathway and glycolysis [194].