KMT2A and acute myeloid leukemia: Studies on murine models of MLL-AF9-induced AML revealed an essential role for AMPK at the level of leukemic stem cells; in fact, AMPK deletion inhibited leukemogenesis and depleted LSCs by reducing the expression of the glucose transporter GLUT1, reducing glucose flux and inducing oxidative stress in the hypoglycemic bone marrow microenvironment [176].