PPARD and acute myeloid leukemia: HLX overexpression leads to downregulation of genes encoding electron transport chain components and upregulation of PPARδ (Perixosome Proliferator Activated Receptor delta) gene expression and results also in AMPK (AMP-activated Kinase); pharmacological modulation of PPARδ signaling relieves the HLXL-induced myeloid differentiation block, while AMPK inhibition reduces the viability of AML cells [257].