Various agents, such as anti-leukemic drugs [283], synthetic triterpenoids [290], triptolide [291], the multikinase inhibitor sorafenib [292], AKT inhibitors [293], the poly (ADP-ribose) polymerase inhibitor olaparib [294] are able to render AML blasts sensitive to TRAIL-induced apoptosis. Here, TNFSF10 is linked to acute myeloid leukemia.