The study of s-AMLs allowed to define a mutational pattern typically associated with these leukemias and involving the presence of a mutation in SRSF2, SF3B1, U2AF1, ZRSR2, ASXL1, EZH2, BCOR or STAG2, genes commonly mutated in myelodysplastic syndromes [40]; three genetic alterations are under-represented in s-AML compared to de novo-AMLs and are represented by NPM1 mutations, MLL and CBF rearrangements [40]. This evidence concerns the gene EZH2 and leukemia.