SLC2A5 and acute myeloid leukemia: Given the high rate of glucose utilization by proliferating leukemic progenitors, this sugar may become insufficient in the bone marrow microenvironment; thus, it is surprising that AML cells are prone to fructose uptake via the upregulated expression of the fructose transporter GLUT5, whose elevated expression in leukemic blasts is associated with poor outcome [142].