BCL2 and acute myeloid leukemia: Thus, Moujhalled and coworkers have shown that the combination of BH3-mimetics able to target both BCL-2 (S55746) and MCL-1 (S63845) was able to induce a pronounced cytotoxic effect on AML cells, active against a broad spectrum of poor risk genotypes, including primary chemoresistant AMLs [116].