Marconi and coworkers have explored abnormalities of autophagy machinery in AML patients and found that autophagy alteration (ULK1 CHR11, ULK1 CHR17, BECN1, ATG14, AMBRA1, UVRAG, ATG14, ATG9A, ATG9B, PIK3C3, PIK3R4) was associated with poor prognosis and with complex karyotype and TP53 mutation [347]. The gene discussed is ATG14; the disease is acute myeloid leukemia.