Clinical experience concerning the use of L-asparaginase in AML is limited to the use of Ecoli-derived Asparaginase in association with multi-agent chemotherapeutic regimens in patients with relapsed/refractory disease and as first-line therapy in patients who do not accept blood transfusions; more recently, some patients with relapsed/refractory AML were treated with L-ASP from Erwinia chrysanthemi in the context of the clinical trial NCT02283190. Here, ASPG is linked to acute myeloid leukemia.