DNMT3A and acute myeloid leukemia: In old AML patients (i.e., ≥75 years) the frequency of TET2 (42%), SRSF2 (25%) and ASXL1 (21%) was higher than in adult AML patients, while DNMT3A and NPM1 mutations were observed at comparable frequencies in these two groups of AMLs; finally, FLT3-ITD mutations are less frequent in old than in adult AML patients [39].