MYC and Familial prostate cancer: Aerobic glycolysis is increased in prostate cancer due in part to genomic loss of the PTEN (phosphatase and tensin homolog) locus, leading to activation of the PI3K/AKT pathway, and 8q amplification, including of the Myc gene, which occurs in up to 70% and 30% of prostate cancers, respectively [7].