The fact that the incidence of metastases is not eliminated entirely in this study suggests either that knockdown of Ldha/LDH-5 activity was initiated in most animals after tumors had advanced to the state where cancer cell dissemination was occurring, or that certain tumors/tumor cells compensate for the loss of Ldha and, after a lag period, are capable of undertaking invasion and metastasis. The gene discussed is LDHA; the disease is neoplasm.